Flow-through sensors are therefore more suitable for addressing
real (non-academic) problems than are probe-type sensors. However, some of their well-known drawbacks, including poor selectivity, low precision and sensitivity, and a lack of durability, which are dependent on the particular ingredients involved in the recognition process, remain unsolved. However, the use of continuous configurations coupled on-line to flow-through sensors can help to indirectly improve the performance of many such sensors. The introductory chapter provides an overview of (bio)chemical sensors and their impact on Analytical Chemistry. Essential concepts of flow-through (bio)chemical sensors including their definition, classification, the types of flow-cells where the sensing microzone can be accommodated, continuous flow configurations to which they can be coupled, the measurement modes
available and the types of transient signals obtained.
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